![]() In addition, Belides has been found to significantly decrease the release of the peptide hormone endothelin (ET-1), the binding capacity of alpha-MSH (melanocyte-stimulating hormone) on the melanocortin receptor-1 (MC1-R) and also melanosome uptake mechanisms. ![]() Tests carried out on melanoma cells (B16V) have shown that Belides controls transcription of tyrosinase expression, thus inhibiting its synthesis. Results of a comparative study conducted with Belides and arbutin, used at equivalent polyphenol concentrations, revealed Belides was about twice as active as arbutin. The fraction of polyphenols is known to inhibit tyrosinase enzymatic activity. ![]() ![]() Surprisingly, Belides was found to exhibit a strong inhibitory effect on melanogenesis (patent pending). The presence of these constituents suggests that this active produces a variety of effects which are also used in phytomedicine. A novel botanical ingredient – trade name: BelidesTM – obtained from daisy flower blossoms (Bellis perennis L.) consists of bioactive constituents such as saponins (triterpene glycosides), polyphenols and polysaccharides.
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