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![]() In addition, Belides has been found to significantly decrease the release of the peptide hormone endothelin (ET-1), the binding capacity of alpha-MSH (melanocyte-stimulating hormone) on the melanocortin receptor-1 (MC1-R) and also melanosome uptake mechanisms. ![]() Tests carried out on melanoma cells (B16V) have shown that Belides controls transcription of tyrosinase expression, thus inhibiting its synthesis. Results of a comparative study conducted with Belides and arbutin, used at equivalent polyphenol concentrations, revealed Belides was about twice as active as arbutin. The fraction of polyphenols is known to inhibit tyrosinase enzymatic activity. ![]() ![]() Surprisingly, Belides was found to exhibit a strong inhibitory effect on melanogenesis (patent pending). The presence of these constituents suggests that this active produces a variety of effects which are also used in phytomedicine. A novel botanical ingredient – trade name: BelidesTM – obtained from daisy flower blossoms (Bellis perennis L.) consists of bioactive constituents such as saponins (triterpene glycosides), polyphenols and polysaccharides. ![]() Adobe Illustrator was expensive and not as easy to use as Corel Draw. Candy Apple, I thought was pretty good but none of the them came anywhere close to what I was looking for. There was Vector Designer, Inkscape and recently I tried out Candy Apple. I did try out a number of vector graphics applications for Mac. After leaving Windows, I had no desire to mess about with having Windows on my Mac. I was disappointed there wasn’t a Mac version of Corel Draw and their only suggestion was to use the Windows version in a virtual machine. ![]() I was an expert user of Corel Draw having used it on a daily basis for 12 years and I’d never been tempted to try using Adobe Illustrator. It has taken a long time to find the Best Adobe Illustrator alternative Due to my background in art and design and having a business as a signwriter, I wanted to have a good application for vector art. ![]() I moved to the Mac from Windows about eight or nine years ago now. I have the right to end this auction at any time. Please consider my 100% positive feedback when bidding on this item. The drop outs are in excellent shape and there are no dings, dents, or cracks. ![]() There is some minor chain rub on on the chain stay and you can see the two holes drilled in the box gusset behind the bottom bracket but beyond that this thing is very very clean. The stamped Ashtabula forks come with this beauty and are newer than the frame and stamped 1979. ![]() It is hand stamped beginning with 15924, as were the 75's. It was my understanding though that the 1976 models were all stamped with C's for Chatsworth. ![]() As you can see by the pics it appears to be a 1976.the seat stay gusset is not flaired like a 75 should be and the coaster brake tab has the oval shape rather than the double thick rectangular shaped tab as 75's should have. I believe this to be an early 76 but may have. 1976 MONGOOSE with Astabula Fork Serial# 15924(early 76 build) 16 1/2" top tube Here is a rare one. |
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